Endocrine Abstracts

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Hyperthyroidism due to TSH-secreting pituitary adenoma is a rare disease and accounts for 0.4% of all pituitary tumors. About 15% of these tumors show co-secretion of prolactin or growth hormone.We report the case of a 44-year-old man, presenting with sudden onset of tremor and agitation and central thyrotoxicosis (TSH 1.01 μU/ml, fT3 8.44 pmol/l, fT4 30.2 pmol/l). Ultrasound of the thyroid gland and TSH-receptor antibodies were normal. Imaging of t...

Transarterial chemoembolization (TACE) is widely used for treatment of hepatocellular carcinoma (HCC). During this procedure approximately 20 g of iodide is applied by radiopaque material. There is usually high awareness regarding hyperthyroidism in association with contrast enhanced imaging studies and TACE. To date, however, there are no reports regarding the frequency of hypothyroidism after this procedure, although high doses of iodide can also inhibit the synthesis of thy...

KLF11 is a pancreas enriched member of the Sp1/KLF transcription factor family which plays an important role in mammalian gene regulation. Previously we demonstrated that human (h)KLF11) inhibits human insulin promoter (hInsP) activity in rodent beta-cell lines via an unknown mechanism. Here we present results from ongoing experiments in which we test the hypothesis that KLF11 interferes with the major hInsP transactivator PDX1. We performed transient cotransfections of INS-1E...

Within the exocrine pancreas, p8 expression is induced by pancreatitis and protects exocrine tissue from inflammatory damage via inhibition of NFκB. In previous work, we investigated the role of p8 within the endocrine pancreas and characterised p8 as a glucose-dependent mediator of beta cell proliferation. Here we investigate the hypothesis that p8 protects beta cells from cell damage by the diabetogenic drug STZ. We investigated native and transiently transfected INS-1E...

Objective: Hypokalemic Conn’s syndrome is a rare disease with a prevalence of 0.5% in unselected hypertensive populations. However, recent studies indicate a higher prevalence of a milder variant of Conn’s syndrome, reaching 10% in some studies. Long term outcome and health care costs of hypo- and normokalemic variants are largely unknown. The National Conn’s Registry is an initiative to create a national database of sufficient epidemiological strength to invest...

Objective: Primary aldosteronism (PA) is associated with vascular end organ damage. We evaluated the newly established German Conn’s Register for evidence of renal impairment and compared the data with renal function from hypertensive subjects from an epidemiologic cohort.Methods: The registry was founded in 2006 and has at present 7 participating centres in 5 locations. Data are entered in a central electronic database. Up to July 2007 555 patients...